Monique C. de Jong, MD
The author of this thesis was born on August 29th, 1982 in Leiden, The Netherlands. In 2000 she graduated cum laude from the Bernardinuscollege (Gymnasium) in Heerlen and went to medical school in Utrecht. During her studies she became interested in cell biology, oncology and radiology and therefore did an internship at the department of Radiation Oncology of the Princess Margaret Hospital (Toronto, Canada). During this internship she learned about the existence of radiobiology and decided she wanted to become a radiation oncologist and radiobiologist. In the final year of her training she did a research internship in the group of prof.dr. Adrian C. Begg at the Netherlands Cancer Institute – Antoni van Leeuwenhoek. After obtaining her Medical Degree in 2007, she continued her research on gene expression profiles to predict radioresistance of head and neck cancer. This research was funded by a joint KWF (Dutch Cancer Society) project supervised by prof.dr. Adrian C. Begg, prof.dr. Michiel W.M. van den Brekel, dr. Frank J. Hoebers, prof. dr. Coen R.N. Rasch and prof.dr. Marcel Verheij. The research was combined with a residency at the department of Radiation Oncology at the same institute. On December 1st, 2017 she will finalize her radiation oncology residency (supervisors: drs. Joost L. Knegjens and dr. Astrid N. Scholten).
de Jong MC, Pramana J, Knegjens JL, Balm AJ, van den Brekel MW, Hauptmann M, Begg AC, Rasch CR. HPV and high-risk gene expression profiles predict response to chemoradiotherapy in head and neck cancer, independent of clinical factors. Radiotherapy and oncology 2010;95:365–70.
Available from: http://www.ncbi.nlm.nih.gov/pubmed/20346528
de Jong MC, Pramana J, van der Wal JE, Lacko M, Peutz-Kootstra CJ, de Jong JM, Takes RP, Kaanders JH, van der Laan BF, Wachters J, Jansen JC, Rasch CR, van Velthuysen ML, Grénman R, Hoebers FJ, Schuuring E, van den Brekel MW, Begg AC. CD44 expression predicts local recurrence after radiotherapy in larynx cancer. Clinical cancer research 2010;16: 5329–38.
Available from: http://www.ncbi.nlm.nih.gov/pubmed/20837694
Egelmeer AG, Velazquez ER, de Jong JM, Oberije C, Geussens Y, Nuyts S, Kremer B, Rietveld D, Leemans CR, de Jong MC, Rasch C, Hoebers F, Homer J, Slevin N, West C, Lambin P. Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: a cohort study based on 994 patients. Radiotherapy and oncology 2011;100(1):108-15.
Available from: http://www.ncbi.nlm.nih.gov/pubmed/21784544
Schaaf MB, Cojocari D, Keulers TG, Jutten B, Starmans MH, de Jong MC, Begg AC, Savelkouls KG, Bussink J, Vooijs M, Wouters BG, Rouschop KM. The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia. Radiotherapy and oncology 2013;108:529–34.
Available from: https://www.ncbi.nlm.nih.gov/pubmed/23849170
de Jong MC, Ten Hoeve JJ, Grénman R, Wessels LF, Kerkhoven R, Te Riele H, van den Brekel MW, Verheij M, Begg AC. Pretreatment microRNA Expression Impacting on Epithelial-to-Mesenchymal Transition Predicts Intrinsic Radiosensitivity in Head and Neck Cancer Cell Lines and Patients. Clin Cancer Res 2015;21:1–10.
Available from: https://www.ncbi.nlm.nih.gov/pubmed/26265694
de Jong MC, Begg AC, te Riele H, Verheij M, van den Brekel MWM. Comparing hypoxia signatures in head and neck cancer. Submitted.
de Jong MC, Begg AC, Verheij M, van den Brekel MWM. Comparing published prognostic signatures in head and neck cancer. Manuscript in preparation.
‘Can gene expression predict response to radiotherapy of head and neck cancer?’, proffered paper, ESTRO, September 2008.
‘Prediction of local recurrence after radiotherapy in head and neck cancer by expression profiling’, proffered paper, ICTR, March 2009.
‘Prediction of local recurrence after radiotherapy in head and neck cancer by expression profiling’, proffered paper award, Netherlands Society for Radiobiology, April 2009.
‘CD44 as a predictive marker for outcome after radiotherapy’, Staff meeting dept. of Experimental Therapy NKI-AvL, October 2009.
‘Potential predictors for radiosensitivity in head and neck squamous cell carcinoma’, invited speaker at OncoRay Dresden, September 2013.
‘Predictors of recurrence after radiotherapy in head and neck squamous cell carcinoma’, Staff meeting dept. of Radiotherapy NKI-AvL, April 2014.
‘MicroRNAs and radioresistance in head and neck cancer’, invited speaker, ESTRO, August 2014.
‘Hypoxia gene expression in head and neck cancer – same same but different’, CERRO, January 2015.
‘Gene expression to predict prognosis of head & neck cancer’, CERRO, January 2016.
‘Prognostic gene expression signatures in HNSCC’, invited speaker, Workshop Biomarkers for Radiation Oncology, OncoRay Dresden, May 2016.
‘The new ‘Rs’ in radiation biology’, teaching lecture, ESTRO, May 2016.
‘Genetic biomarkers: mRNA/miRNA profiles’, teaching lecture, pre-meeting course ESTRO, May 2017.
‘Stereotactic radiotherapy for oligometastases’, AvL Symposium, June 2017.
‘The radiobiology of radiosurgery’, invited speaker, Symposium 15 years Gamma Knife Center Tilburg, June 2017.
‘Deterministic effects: variables’, teaching lecture, Boerhaave cursus stralingshygiëne, Leiden, September 2017.