Contents

Supplementary methods

Supplementary table 5.1: Patient characteristics series 1: 91 HNSCC stage III-IV radiochemotherapy patients.

Supplementary table 5.2: Patient characteristics series 2: 99 larynx/ oropharynx radiotherapy patients.

Supplementary table 5.3: Patient characteristics series 3: 34 larynx radiotherapy patients.

Supplementary figure 5.1 Kaplan-Meier curves for all published and in vitro hypoxia profiles.

Supplementary figure 5.2: Kaplan-Meier curve for the combined chronic hypoxia profile.