Acknowledgments

The authors thank Wim Brugman, Janneke Kruizinga, and Marja Nieuwland for conducting the microarray experiments; Sander Canisius and Arno Velds for their advice on statistical modeling; and Iris de Rink for processing the raw miR sequencing data. They also acknowledge the NKI-AVL Core Facility Molecular Pathology and Biobanking (Dennis Peters, Annegien Broeks, and Linde Braaf) for supplying NKI-AVL Biobank material and laboratory support. They thank Manon Verwijs for her help with experiments.

Financial support

This study was partly funded by the Dutch Cancer Society (NKI-2007-3941) and the Verwelius foundation.