1.1 <\/strong>Cancer<\/strong><\/a><\/p>\n 1.2 <\/strong>Head and neck cancer<\/strong> 1.3 <\/strong>Radiotherapy for head and neck cancer and reasons for its failure<\/strong> 1.4 <\/strong>Thesis outline\/aim\/scope<\/strong><\/a><\/p>\n 1.5<\/strong> References<\/strong><\/a><\/p>\n 6.1 The road to discovery of clinically relevant biomarkers for radiotherapy response<\/a><\/strong><\/p>\n 6.2 Is more research needed?<\/a> 6.3 Rubbish in, rubbish out (quote Adrian C. Begg)<\/a><\/strong> 6.4 How to individualize future treatment?<\/a><\/strong><\/p>\n 6.5<\/strong> References<\/strong><\/a><\/p>\n Summary\/Samenvatting<\/strong><\/a><\/p>\n About the author<\/a>
\n<\/a>1.2.1 Definition
\n1.2.2 Epidemiology
\n1.2.3 Etiology
\n1.2.4 Methods to study a head and neck tumor
\n1.2.5 Staging
\n1.2.6 Management
\n1.2.7 Prognosis
\n1.2.8 Quality of life<\/p>\n
\n<\/a>1.3.1 Treatment characteristics
\n1.3.2 Patient characteristics
\n1.3.3 Tumor biology<\/p>\nChapter 2:<\/a> HPV and high-risk gene expression profiles predict response to chemoradiotherapy in head and neck cancer, independent of clinical factors<\/h3>\n
Chapter 3:<\/a> CD44 expression predicts local recurrence after radiotherapy in larynx cancer<\/h3>\n
Chapter 4:<\/a> Pretreatment microRNA expression impacting on epithelial-to-mesenchymal transition predicts intrinsic radiosensitivity in head and neck cancer cell lines and patients<\/h3>\n
Chapter 5:<\/a> Comparing hypoxia signatures in head and neck cancer<\/h3>\n
Chapter 6:<\/a> General discussion<\/h3>\n
\n<\/strong>6.2.1 Patient numbers
\n6.2.2 Cutoff values
\n6.2.3 Interactions between factors
\n6.2.4 Prognostic vs. predictive factors<\/p>\n
\n6.3.1 The pre-treatment sample
\n6.3.2 Just (messenger) RNA?
\n6.3.3 Need for adequate biomarkers of processes<\/p>\nAppendices<\/h3>\n
\n<\/strong>Curriculum vitae
\nList of publications\/ presentations<\/p>\n