PURPOSE:<\/span> MATERIAL AND METHODS:<\/span> RESULTS:<\/span> CONCLUSIONS:<\/span> PURPOSE: The purpose of this study was to combine gene expression profiles and clinical factors to provide a better prediction model of local control after chemoradiotherapy for advanced head and neck cancer. MATERIAL AND METHODS: Gene expression data were available for a series of 92 advanced stage head and neck cancer patients treated with primary […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":15,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width.php","meta":{"footnotes":""},"class_list":["post-167","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.moniquedejong-research.eu\/phd\/wp-json\/wp\/v2\/pages\/167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.moniquedejong-research.eu\/phd\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.moniquedejong-research.eu\/phd\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.moniquedejong-research.eu\/phd\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.moniquedejong-research.eu\/phd\/wp-json\/wp\/v2\/comments?post=167"}],"version-history":[{"count":10,"href":"http:\/\/www.moniquedejong-research.eu\/phd\/wp-json\/wp\/v2\/pages\/167\/revisions"}],"predecessor-version":[{"id":950,"href":"http:\/\/www.moniquedejong-research.eu\/phd\/wp-json\/wp\/v2\/pages\/167\/revisions\/950"}],"up":[{"embeddable":true,"href":"http:\/\/www.moniquedejong-research.eu\/phd\/wp-json\/wp\/v2\/pages\/15"}],"wp:attachment":[{"href":"http:\/\/www.moniquedejong-research.eu\/phd\/wp-json\/wp\/v2\/media?parent=167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/span><\/strong>The purpose of this study was to combine gene expression profiles and clinical factors to provide a better prediction model of local control after chemoradiotherapy for advanced head and neck cancer.<\/p>\n
\n<\/span><\/strong>Gene expression data were available for a series of 92 advanced stage head and neck cancer patients treated with primary chemoradiotherapy. The effect of the Chung high-risk and Slebos HPV expression profiles on local control was analyzed in a model with age at diagnosis, gender, tumor site, tumor volume, T-stage and N-stage and HPV profile status.<\/p>\n
\n<\/span><\/strong>Among 75 patients included in the study, the only factors significantly predicting local control were tumor site (oral cavity vs. pharynx, hazard ratio 4.2 [95% CI 1.4-12.5]), Chung gene expression status (high vs. low risk profile, hazard ratio 4.4 [95% CI 1.5-13.3]) and HPV profile (negative vs. positive profile, hazard ratio 6.2 [95% CI 1.7-22.5]).<\/p>\n
\n<\/strong><\/span>Chung high-risk expression profile and a negative HPV expression profile were significantly associated with increased risk of local recurrence after chemoradiotherapy in advanced pharynx and oral cavity tumors, independent of clinical factors.<\/p>\n","protected":false},"excerpt":{"rendered":"